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    Add: 9th Floor,Building E, Anhui Land Square, No.288, Huaining Road, Hefei, Anhui, China.

    +86-551-63840330
    +86-551-63840550
     
    +86-13865958972 
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    Location:Home > Products > Western Medicines > New Products

    New Products

    Compound α-Ketoacid Tablets

    Compound α-Ketoacid Tablets
    • Product Code :AMC12064
    • Specification:Compound
    • Shelf life:Three years
    • Registration dossiers: Yes

    DESCRIPTION

    COMPOSITION

    Each tablet contains:

    D,L-a-Ketoisoleucine Calcium…………………………………………………67mg

    a- Ketoleucine Calcium…………………………….………………………… 101mg

    a-Ketophenylalanine Calcium………………………………………..…………68mg

    a-Ketovaline Calcium……………………………………………………...……86mg

    D.L-α-Hydroxymethionine Calcium……………………………………………59mg

    L-Lysine Acetate……………………………………………………………….105mg

    L-Threonine………………………………………………………………..……53mg

    L-Tryptophan……………………………………………………………………23mg

    L-Histidine………………………………………………………………………38mg

    L-Threonine……………………………………………………………………...30mg

    DESCRIPTION

    This compound tablets contain 4 kinds of Calcium Amino Acid, 1 kind of Calcium Hydroxyl-amino Acid and 5 kinds of Amino Acids.

    CHARACTERS

    Compound α-Ketoacid Tablets are yellow film coated. The tablet color is white after film removed. For each tablet, the total nitrogen content is 36mg and the total calcium content reaches 1.25mmol which equals approximately to 50mg.

    PHARMACOLOGY AND TOXICOLOGY

    Compound α-Ketoacid Tablets can supply the essential amino acids and reduce the intake of ammonia nitrogen. Ketone or hydroxyamino acid does not contain amidogen, which can help them utilize the nitrogen from non-essential amino acids to transfer  into amino acids. This can reduce the synthesis of urea as well as the accumulation  of the uremic toxic products. Ketone or hydroxyamino does not cause the ultrafiltration of remnant nephron, alleviate the renal hyperphosphatemia and secondary hyperparathyroidism and improve the status of renal osteodystrophy. With the low-protein diet together, Compound α-Ketoacid Tablets can reduce the intake of nitrogen and at the same time avoid the adverse consequences caused by insufficient protein intake and malnutrition.The results of toxicology researches indicate that Compound α-Ketoacid Tablets has low toxicity. Chronic toxicology researches show that minimum toxicity dose of dog is 1200 mg/day and rat 2700 mg/day. After conversion, the dosage for the human  body (70 kg) is 84 g/day according to dog dosage and 189 g/day according to rat dosage.

    This product has no embryo toxicity.

    PHARMACOKINETICS

    For the normal individuals, the plasma level will rise 10 minutes after taking ketone  or hydroxyamino acid, at this time the plasma concentration is up to five times the initial level which will reach the peak after 20-60 minutes and decrease to the normal level after 90 minutes. The ketone or hydroxyamino acid in the plasma and corresponding amino acid concentration increase at the same time, which shows the fast transamination of ketone or hydroxyamino. As the ketone or hydroxyamino acid in human body has its own distribution pathway, the intake from external can enter metabolic cycle fast, and their catabolism pathway is the same with amino acids.

    USAGE

    With the low-protein diet together, Compound α-Ketoacid Tablets can be taken as prevention and treatment of damage caused by protein metabolic as chronic renal insufficiency, usually for patients with glomerular filtration rate lower than for 25ml per minutes. Low protein diet requires adult daily requirement protein intake of 40g or less than 40g.

    DOSAGE

    By oral administration. 3 times a day, 4 to 8 tablets every time. Swallow whole tablets during meals. If necessary, be directed by doctor. This dosage is calculated according to 70kg adult weight.For patients with glomerular filtration rate lower than for 25ml per minutes, this product can be used long time with with no more than 40 grams daily (adult) of low protein diet.

    ADVERSE EFFECTS

    Hypercalcemia may occur. When hypercalcemia occurs, the patients shall reduce the intake of Vitamin D. When hypercalcemia continues, the patients shall reduce the intake dosage of this product and the intake of other calcium substances.

    TABOOS

    Metabolism disorders of hypercalcemia and amino acid.Hereditary phenylacetone urine patients shall pay attention to the containing of phenylalanine.

    PRECAUTIONS

    The medicine is suggested to be taken during the meal so as to make full absorbed and transfer into corresponding amino acid. The calcium level in serum shall be monitored regularly and adequate intake of calorie shall be ensured.

    Keep out of the reach of children.

    Do not take the products out of expiration time.

    INDICATION FOR PREGNANT AND NURSING MOTHER

    None experience for usage of pregnant and nursing mother.

    DRUG INTERACTIONS

    This product can lead the rising of calcium level in serum while taken with other calcium medicines at same time.

    For uremic patients taking this product, if they take aluminum hydroxide drugs at  thesame time, the dosage of aluminum hydroxide drugs shall be reduced.  Pay attention  to the decrease of phosphorus level in serum.In order not to affect the absorption of drugs, other drugs which can form slightly solubility compounds combined with calcium shall not be taken with this products at the same time, including tetracycline, quinolone like ciprofloxacin and norfloxacin, iron, fluoride and drugs containing estramustine, etc. The interval between taking of this product and these referred drugs above shall not be less than 2 hours.The rise of calcium level in serum can increase the sensitivity of cardiac glycoside drug and therefore increase the risk of arrhythmia.

     

    Hits:  UpdateTime:2016-07-01 10:42:03  【Printing】  【Close】
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