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Magnesium sulfate injection is indicated in the following conditions:
l Convulsions (treatment) - Intravenous magnesium sulfate (magnesium sulfate injection) is indicated for immediate control of life-threatening convulsions in the treatment of severe toxemias (pre-eclampsia and eclampsia) of pregnancy and in the treatment of acute nephritis in children.
l Hypomagnesemia (prophylaxis and treatment) - Magnesium sulfate (magnesium sulfate injection) is indicated for replacement therapy in magnesium deficiency, especially in acute hypomagnesemia accompanied by signs of tetany similar to those of hypocalcemia.
l Magnesium sulfate (magnesium sulfate injection) is also used to prevent or treat magnesium deficiency in patients receiving total parenteral nutrition.
l Tetany, uterine (treatment) - Magnesium sulfate (magnesium sulfate injection) is indicated in uterine tetany as a myometrial relaxant.
Magnesium sulfate (magnesium sulfate (magnesium sulfate injection) injection) should be given very cautiously in the presence of serious impairment of renal function since it is excreted almost entirely by the kidneys.
When barbiturates, narcotics, or other hypnotics (or systemic anesthetics) are to be given in conjunction with magnesium, their dosage should be adjusted with caution because of the additive central depressive effects of magnesium.
Pregnancy - Teratogenic effects: Pregnancy category C. Animal reproduction studies have not been conducted with Magnesium Sulfate Injection, USP 50%. It is also not known whether Magnesium Sulfate Injection, USP 50% can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity. Magnesium Sulfate Injection, USP 50% should be given to a pregnant woman only if clearly needed.