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Griseofulvin is primarily indicated in conditions like Dermatophytic infections, Fungal infection, Parkinson’s disease.
Adverse reactions of griseofulvin are uncommon. Nausea, diarrhea, headache, skin eruptions and photosensitivity are occasionally observed. Hepatotoxicity and neurological side effects may rarely occur.
Griseofulvin can interact with blood thinners and birth control pills.
Precautions & Warning:
Caution should be exercised in patients with history of liver disease, porphyria, lupus, or history of alcohol abuse, any allergy, who are taking other medications, during pregnancy and breastfeeding.
Avoid exposure to sunlight.
Use in Pregnancy and Nursing Mothers:
Griseofulvin is assigned to pregnancy category C. Animal studies have revealed evidence of embryotoxicity and teratogenicity. There are no controlled data in human pregnancies; however, there are reports of congenital anomalies, including cases of conjoined twins in two women, as well as increased risk of spontaneous abortion. The manufacturer considers griseofulvin use to be contraindicated during pregnancy. There are no data on the excretion of griseofulvin into human milk.
Treatment/antidote in The Event of Overdose:
Treatment is symptomatic and supportive. There is no specific antidote for treatment of griseofulvin intoxication.